Fidelity Oligos, LLC (Gaithersburg, MD) specializes in the synthesis of modified and highly modified DNA/RNA oligonucleotides and analogues.

For over 20 years (previously within Fidelity Systems, Inc.) we have gained an extensive expertise that allows us to successfully synthesize difficult and unusual constructs.

Having synthesized

• biotinylated oligos (Moreno et al. Nucleic Acids Research 2009, 37, 1925-1935)
• antagomirs and 2’-OMe RNA oligos (da Costa Martins et al. Nature Cell Biology 2010, 1220-1227; Wang et al. Cancer Cell, 2008, 14, 369-381; Angelo Veronese et al. Cancer Res., 2010, 70, 3140-3149),
• trithiol modified oligos (Claridge et al. Am. Chem. Soc. 2008, 130, 9598-9605; Phares et al. Anal. Chem. 2009, 81, 1095-1100; Zheng et al. Angew. Chem. Int. 2011, 50, 1-6),
• oligos with extraordinary long tethers (Dejardin et al. Cell 2009, 136, 175-186; Bakalova et al. Am. Chem. Soc. 2005, 127, 11328-11335),
• force sensors (Shroff et al. Nano Lett. 2005, 5, 1509-1514.),
• plasmon rulers (Reinhard et al. Nano Lett. 2005, 5, 2246-2252; Sonnichsen et al. Nature Biotechnology, 2005, 23, 741-745 ; Reinhard et al. PNAS 2007, 104, 2667-2672),
• pteridine containing oligos (Datta et al. PNAS 2010, 107, 17980-17985)
• and many, many more non-vanilla oligos

We have helped to advance the research of others. We are happy to assist you!

Apart from custom oligonucleotides Fidelity Oligos offers some unique specialty phosphoramidites including biotin amidites, amino linkers and spacers with long and super long PEG-like tethers as well as MOX/SUC precursor monomers for post synthetic derivatization.

We also do custom synthesis of some small molecules such as unusual phosphoramidites, nucleoside  triphosphates and NHS-esters.

We pride ourselves in making high quality products for both industry and academia and…

…  we love to be challenged.